Fused pyrimidine-based hydroxamate derivatives

A compound of Formula (I);

• wherein X, Y and Z are independently selected from N, CHR3 or CR3, wherein at least one of X, Y or Z is N;
• is a single or double bond, as valency allows;
• R1 is selected from the group consisting of optionally substituted amino, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl and optionally substituted heteroaryl;
• R2 is selected from the group consisting of halogen, optionally substituted amino, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl and optionally substituted heteroaryl;
• R3 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted amino, and optionally substituted heterocycloalkyl;
• R4 is optionally substituted alkyl;
• at least one of R1, R2, R3 or R4 is further independently substituted by an hydroxamate group -L1-R5-L2-R6-L3-CON(Ra)ORb, wherein;
• Ra and Rb are hydrogen;
• L1, L2 and L3 are independently selected from the group consisting of a bond, optionally substituted alkyl, optionally substituted alkenyl and optionally substituted alkynyl;
• R5 and R6 are independently selected from the group consisting of a bond, O, NRc, S(O)n, optionally substituted amide, optionally substituted heterocycloalkyl, optionally substituted aryl and optionally substituted heteroaryl;
• wherein;
• Rc is independently selected from the group consisting of hydrogen or, optionally substituted alkyl;
• and
• n is an integer from 0 to 2;
• or a pharmaceutically acceptable form thereof.