S-imino-S-oxo iminothiazine compounds as bace inhibitors, compositions, and their use

A compound, or a pharmaceutically acceptable salt thereof, said compound having the structural Formula (I):

• or a tautomer thereof having the structural Formula (I′):
• or pharmaceutically acceptable salt thereof, wherein:
• RN is selected from the group consisting of alkyl and -alkyl-cycloalkyl,
• wherein said alkyl and said -alkyl-cycloalkyl are optionally unsubstituted or substituted with one or more halogen,
• and wherein each of 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl is optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• R1A and R1B are each independently selected from the group consisting of H, halogen, alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl,
• wherein each said alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl of R1A and R1B is optionally independently unsubstituted or substituted with one or more halogen,
• and wherein 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl is optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• R2A and R2B are each independently selected from the group consisting of H, halogen, alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloaklyl,
• wherein each said alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloaklyl of R2A and R2B is optionally independently substituted with one or more halogen,
• and wherein 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl is optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• R3 is selected from the group consisting of H, alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl,
• wherein each said alkyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl is optionally substituted with one or more halogen,
• and wherein 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl is optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• ring A is selected from the group consisting of aryl and heteroaryl;
• m is 0 or more, with the proviso that the value of m does not exceed the number of substitutable hydrogen atoms on ring A;
• each RA (when present) is independently selected from the group consisting of halogen, oxo, —OH, —CN, alkyl, —O-alkyl, and cycloalkyl,
• wherein said alkyl, —O-alkyl, and cycloalkyl are each optionally independently unsubstituted or substituted with one or more halogen, and
• wherein 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl and said —O-alkyl, are optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• ring B is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
• n is 0 or more, with the proviso that the value of n does not exceed the number of substitutable hydrogen atoms on ring B;
• each RB (when present) is independently selected from the group consisting of halogen, oxo, —CN, —SF5, —OSF5, —OR4B, —SR4B, alkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, and heteroaryl,
• wherein said alkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl, aryl, and heteroaryl of RB are each optionally independently unsubstituted or substituted with one or more groups independently selected from R5, and wherein 1 or 2 non-adjacent, non-terminal carbon atoms of said alkyl are optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• each R4B is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl,
• wherein each said alkyl, alkenyl, alkynyl, cycloalkyl, -alkyl-cycloalkyl, heterocycloalkyl, -alkyl-heterocycloalkyl of R4B is unsubstituted or optionally substituted with one or more fluorine,
• and wherein 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl are optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—;
• and
• each R5 (when present) is independently selected from the group consisting of halogen, —OH, —CN, alkyl, —O-alkyl, cycloalkyl, -alkyl-cycloalkyl, —O-cycloalkyl, heterocycloalkyl, and -alkyl-heterocycloalkyl,
• wherein each said alkyl, —O-alkyl, cycloalkyl, -alkyl-cycloalkyl, —O-cycloalkyl, -heterocycloalkyl, and -alkyl-heterocycloalkyl are optionally substituted with one or more fluorine,
• and wherein 1 or 2 non-adjacent, non-terminal carbon atoms in said alkyl are optionally independently replaced with —O—, —NH—, —N(alkyl)-, —S—, —S(O)—, or —S(O)2—.