Back to results
US 9,957,261 B2Granted
6-amino-5,6,7,8-tetrahydronaphthalen-2-yl or 3-aminochroman-7-yl derivatives
AssigneeHoffman-La Roche Inc.
InventorsGiuseppe Cecere, Guido Galley, Annick Goergler, Roger Norcross, Philippe Pflieger, Alina Tirla, Philipp Schmid
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds TAAR receptor antagonists of formula I wherein X, R, L, Ar and R1 are as described herein, compositions containing compounds of formula I, methods of manufacture of compounds of formula I and methods of treating psychiatric disorders with compounds of formula I.
Claims10
A compound of formula (I) wherein:
- L is —C(O)NH—, —NHC(O)—, —NH— or —NHC(O)NH—;
- Ar is phenyl, benzyl, naphthyl or first heteroaryl, said first heteroaryl selected from the group consisting of pyridinyl, pyrazolyl, pyrimidinyl, isoxazolyl and pyrazinyl, wherein Ar may be optionally substituted by one, two or three R1;
- R1 is, in each occurrence, independently selected from the group consisting of (a) hydrogen, (b) lower alkyl, (c) lower alkoxy, (d) halogen, (e) cyano, (f) cycloalkyl, (g) NHC(O)-lower alkyl, (h) lower alkoxy substituted by halogen, (i) lower alkyl substituted by halogen, (j) phenyl optionally substituted by one or two halogen atoms, CF3O or lower alkyl, and (k) a second heteroaryl selected from furanyl, thiazolyl or thiophenyl each optionally substituted by halogen or lower alkyl;
- X is CH2;
- R is hydrogen or halogen;
- or a pharmaceutically acceptable acid addition salt thereof, and a racemic mixture, enantiomer or mixture of enantiomers.
3 more elements
Dependencies are inferred from the claim text.