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US 9,957,252 B2Granted
Metalloenzyme inhibitor compounds as fungicides
AssigneeDow AgroSciences LLC
InventorsMichael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
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Abstract
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Claims20
A compound of Formula I, or salt thereof, wherein:
- Z is optionally substituted 5-pyrimidinyl, optionally substituted 4-pyrimidinyl, optionally substituted thiazolyl, optionally substituted oxazolyl, or optionally substituted 3-pyridinyl;
- R1 is tert-butyl, optionally substituted with 0, 1, 2 or 3 independent R8;
- R2 is aryl or heteroaryl each optionally substituted with 0, 1, 2 or 3 independent R8;
- R3 is independently H, alkyl, —C(O)alkyl, or —Si(alkyl)3, each optionally substituted with 0, 1, 2 or 3 independent R8;
- R4, R5, R6, and R7 are independently H, alkyl, haloalkyl, alkoxy, halo, or cyano;
- and
- R8 is independently alkyl, thioalkyl, cyano, haloalkyl, cyanoalkyl, hydroxy, alkoxy, halo, haloalkoxy, —C(O)alkyl, —C(O)OH, —C(O)O-alkyl, —SCF3, —SF5, —SCN, or —SO2— alkyl.
4 more elements
Dependencies are inferred from the claim text.