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US 9,957,233 B1Granted
Process for preparing substituted quinolin-4-ol compounds
AssigneesCalitor Sciences, LLC, Sunshire Lake Pharma Co., Ltd.
InventorNing Xi
Life of this patent
Estimating the term…
Abstract
The invention relates to a process for preparing substituted quinolin-4-ol compounds useful for preparing protein tyrosine kinase (PTK) inhibitors which are useful in treating cancer.
Claims16
A process for preparing a compound of Formula (I),
- wherein:
- each R is independently F, Cl, Br, I, CN, (C1-C6)alkyl, ORa, or NRbRc;
- n is 0, 1, 2, 3, or 4;
- each of Ra, Rb and Rc is independently H, (C1-C6)alkyl, (C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, 3-6 membered heterocyclyl, —(C1-C4)alkylene-(3-6 membered heterocyclyl), (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl, or —(C1-C4)alkylene-(5-10 membered heteroaryl), wherein each of the (C1-C6)alkyl, (C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, 3-6 membered heterocyclyl, —(C1-C4)alkylene-(3-6 membered heterocyclyl), (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl and —(C1-C4)alkylene-(5-10 membered heteroaryl) is optionally substituted with 1, 2, 3, or 4 substitutents independently selected from F, Cl, CN, N3, OH, (C1-C6)alkyl, (C1-C6)haloalkyl, and (C1-C6)alkoxy;
- and wherein the compound of Formula (I) is not one of the following compounds:
- the process comprising:
- contacting the compound of Formula (II):
- with a dichlorobenzene of Formula (III):
- to obtain a reaction mixture containing the compound of Formula (I);
- wherein the dichlorobenzene of Formula (III) is
7 more elements
Dependencies are inferred from the claim text.