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US 9,957,232 B2Granted
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate
AssigneeBayer HealthCare LLC
InventorsAlfons Grunenberg, Juergen Stiehl, Katharina Tenbieg, Birgit Keil
Life of this patent
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Abstract
The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide monohydrate, to processes for its preparation, to pharmaceutical compositions comprising it and to its use in the control of disorders.
Claims29
A compound of the formula (II)
A process for the preparation of the compound of the formula (II)
- which comprises dissolution of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl{amino) -3-fluorophenoxy]-N-methylpyridine-2-carboxamide in an inert solvent and adding water until precipitation.
A process for the preparation of the compound of the formula (II)
- which comprises suspension of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino) -3-fluorophenoxy]-N-methylpyridine-2-carboxamide in an aqueous solvent and then stirring or shaking until conversion to the compound of the formula (II).
The compound of the formula (II)
- which shows in the X-ray diffractometry a peak maximum of the 2 Theta angle of 21.2.
Dependencies are inferred from the claim text.