Amido compounds and their use as pharmaceuticals
AssigneesIncyte Holdings Corporation, Incyte Corporation
InventorsWenqing Yao, Jincong Zhuo, Meizhong Xu, Colin Zhang, Brian W. Metcalf, Chunhong He, Ding-Quan Qian
Life of this patent
Estimating the term…
Abstract
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
Claims6
A compound, which is N-methyl-5-[4-(1-{[3-oxo-1′H,3H-spiro[2-benzofuran-1,3′-pyrrolidin]-1′-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide, wherein one or more hydrogen atoms are replaced by deuterium;
- or a pharmaceutically acceptable salt thereof.
A compound, which is N-methyl-5-[4-(1-{[(1R)-3-oxo-1′H,3H-spiro[2-benzofuran-1,3′-pyrrolidin]-1′-yl]carbonyl}cyclopropyl)phenyl]pyridine-2-carboxamide, wherein one or more hydrogen atoms are replaced by deuterium;
- or a pharmaceutically acceptable salt thereof.
A compound, which is N-methyl-5-[4-(1-{[(1R)-3-oxo-1′H,3H-spiro[2-benzofuran-1,3′-pyrrolidin]-1′-yl]carbonyl cyclopropyl)phenyl]pyridine-2-carboxamide, wherein one or more hydrogen atoms are replaced by deuterium.
Dependencies are inferred from the claim text.