Treprostinil derivatives and compositions and uses thereof
AssigneeCorsair Pharma, Inc.
InventorsXiaoming Zhang, Meenakshi S. Venkatraman, Cyrus K. Becker
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Abstract
The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
Claims30
A compound of Formula (I):
- or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof, wherein R1 and R2 independently are selected from the group consisting of:
- hydrogen,
- wherein each moiety that has a stereocenter adjacent to the carbonyl group can have the (R)-stereochemistry or the (S)-stereochemistry or can be racemic at that stereocenter;
- with the proviso that both R1 and R2 are not hydrogen.
A pharmaceutical composition comprising one or more pharmaceutically acceptable excipients or carriers and a compound of Formula (I):
- or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof, wherein R1 and R2 independently are selected from the group consisting of:
- hydrogen,
- wherein each moiety that has a stereocenter adjacent to the carbonyl group can have the (R)-stereochemistry or the (S)-stereochemistry or can be racemic at that stereocenter;
- with the proviso that both R1 and R2 are not hydrogen.
A method of treating a medical condition responsive to treatment with treprostinil, comprising administering to a subject in need of treatment a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof, wherein R1 and R2 independently are selected from the group consisting of:
- hydrogen,
- wherein each moiety that has a stereocenter adjacent to the carbonyl group can have the (R)-stereochemistry or the (S)-stereochemistry or can be racemic at that stereocenter;
- with the proviso that both R1 and R2 are not hydrogen.
Dependencies are inferred from the claim text.