Upconverting nanoparticles
OwnerAmol Punjabiinventor
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Abstract
Provided herein are lanthanide-containing upconverting nanoparticles, methods of their preparation, compositions, and methods of using the same. The polymers and compositions provided herein may be used, for example, in photodynamic therapy.
Claims18
A nanoparticle comprising a rare earth metal fluoride composition according to the formula M1M2F4 wherein M1 is sodium, M2 is the rare earth, and wherein the rare earth metal fluoride composition comprises:
- ytterbium in an amount from about 75 mol % to about 85 mol % of the rare earth present in the composition;
- erbium in an amount from about 1 mol % to about 3 mol % of the rare earth present in the composition;
- and
- yttrium in an amount from about 15 mol % to about 25 mol % of the rare earth present in the composition;
- and wherein the nanoparticle comprises a layer comprising calcium fluoride coating the rare earth metal fluoride composition.
A method of preparing an upconverting nanoparticle comprising reacting in a reaction mixture rare earth trifluoroacetates and sodium trifluoroacetate under conditions sufficient to form a nanoparticle comprising a sodium rare earth tetrafluoride, wherein the rare earth trifluoroacetates comprise:
- ytterbium trifluoroacetate in an amount from about 75 mol % to about 85 mol % of the rare earth trifluoroacetates present in the reaction mixture;
- erbium trifluoroacetate in an amount from about 1 mol % to about 3 mol % of the rare earth trifluoroacetates present in the reaction mixture;
- and
- yttrium trifluoroacetate in an amount from about 15 mol % to about 25 mol % of the rare earth trifluoroacetates present in the reaction mixture;
- and
- subsequently coating the nanoparticle with a shell comprising calcium fluoride.
Dependencies are inferred from the claim text.