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US 9,956,391 B2Granted
Electric pulse generators
AssigneePulse Biosciences, Inc.
InventorsJack Robert Weissberg, Sudeep Deshpande, Chunqi Jiang
Life of this patent
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Abstract
This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. This treatment may prevent at least growth of the lesion.
Claims20
A system for delivery of electrical pulses to tissue comprising:
- a pulse generator configured to generate at least one pulse with an amplitude of at least 1 kV that has a duration of no longer than 1,000 nanoseconds at full-width-at-half-maximum, the pulse generator comprising:
- a tank circuit comprising a first capacitor-inductor pair connected in series with a second capacitor-inductor pair;
- a first switch from a terminal of the circuit to ground;
- and
- a second switch between the pairs switchable to ground;
- and
- a pulse delivery device connected with the pulse generator, the pulse delivery device comprising a delivery electrode and a ground electrode spaced apart such that the at least one pulse from the pulse generator produces an electric field between 10 kV/cm and 100 kV/cm between the electrodes, each electrode having an outer surface, wherein the entire outer surface of at least one of the ground electrode or the delivery electrode is coated with an electrically insulating material thick enough to prevent electrical arcing at 10 kV/cm between the delivery electrode and the ground electrode,
- wherein the pulse generator provides the at least one pulse that is generated to the pulse delivery device.
5 more elements
Dependencies are inferred from the claim text.