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US 9,956,385 B2Granted
Post-processing of a medical device to control morphology and mechanical properties
OwnerPatrick H. Ruaneinventor
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Abstract
A method of forming a coated medical device is described in which a coating including a therapeutic agent dispersed in a polymer or oligomer matrix is applied to an outer surface of the medical device. The coating is then post-processed to selectively remove a substantial portion of the polymer or oligomer matrix from the coating. The post-processed coating is then sterilized.
Claims21
A method of forming a coated medical device comprising:
- applying a coating to an outer surface of a medical device, the coating including a therapeutic agent dispersed in a matrix of a polymer or oligomer excipient;
- post-processing the medical device by immersion in a solvent or solution, thereby selectively removing a substantial portion of the polymer or oligomer excipient from the matrix in which the therapeutic agent is dispersed;
- and
- sterilizing the post-processed medical device,
- wherein the coating comprises less than 50% by weight of the therapeutic agent prior to post-processing, and the coating comprises greater than 50% by weight of the therapeutic agent after post-processing.
2 more elements
Dependencies are inferred from the claim text.