Compositions useful as antibiofilm or antimicrobial agents and methods using same
AssigneeBaylor College of Medicine
InventorsMohammad David Mansouri, Rabih O. Darouiche
Life of this patent
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Abstract
The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The present invention further includes compositions and methods useful for coating medical devices. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on the surface of a medical device or subject's body.
Claims48
A method for preventing or reducing the growth or proliferation of microorganisms and biofilm-embedded microorganisms on at least one surface of a medical device or subject's body, comprising the steps of:
- providing at least one surface of (i) a medical device, or (ii) a subject's body;
- providing a composition comprising α-lipoic acid or an analog thereof selected from the group consisting of lipoamide, dihydrolipoic acid, dihydrolipoamide, an ester derivative of α-lipoic acid, an ester derivative of dihydrolipoic acid, asparagusic acid, an ester derivative of asparagusic acid, 3,3′-dimercapto-isobutyric acid, an ester derivative of 3,3′-dimercapto-isobutyric acid, any salt or solvate thereof, or any combinations thereof, wherein the ester derivative is a methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, benzyl, or stearyl ester, and at least one antimicrobial agent selected from the group consisting of doxycycline, levofloxacin, and gentamicin;
- and
- contacting the at least one surface with the composition in an amount sufficient to prevent or reduce the growth or proliferation of microorganisms and biofilm-embedded microorganisms on the at least one surface.
A coated medical device having at least one surface, wherein the at least one surface is coated with a composition, wherein the coating of the at least one surface prevents or reduces the growth or proliferation of microorganisms and biofilm-embedded microorganisms on the at least one surface, wherein the composition comprises α-lipoic acid or an analog thereof selected from the group consisting of lipoamide, dihydrolipoic acid, dihydrolipoamide, an ester derivative of α-lipoic acid, an ester derivative of dihydrolipoic acid, asparagusic acid, an ester derivative of asparagusic acid, 3,3′-dimercapto-isobutyric acid, an ester derivative of 3,3′-dimercapto-isobutyric acid, any salt or solvate thereof, or any combinations thereof, wherein the ester derivative is a methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, benzyl, or stearyl ester, and at least one antimicrobial agent selected from the group consisting of doxycycline, levofloxacin, and gentamicin.
A method for removing at least a portion of or reducing the number of microorganisms and biofilm-embedded microorganisms attached to at least one surface of a medical device or subject's body, the method comprising the steps of:
- providing at least one surface of (i) a medical device or (ii) a subject's body, wherein the microorganisms and biofilm-embedded microorganisms are attached to the at least one surface,
- providing a composition comprising α-lipoic acid or an analog thereof selected from the group consisting of lipoamide, dihydrolipoic acid, dihydrolipoamide, an ester derivative of α-lipoic acid, an ester derivative of dihydrolipoic acid, asparagusic acid, an ester derivative of asparagusic acid, 3,3′-dimercapto-isobutyric acid, an ester derivative of 3,3′-dimercapto-isobutyric acid, any salt or solvate thereof, or any combinations thereof, wherein the ester derivative is a methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, benzyl, or stearyl ester, and at least one antimicrobial agent selected from the group consisting of doxycycline, levofloxacin, and gentamicin;
- and,
- contacting the composition with the at least one surface in an amount sufficient to remove at least a portion of or reduce the number of microorganisms and biofilm-embedded microorganisms attached to the at least one surface.
A composition comprising α-lipoic acid or an analog thereof selected from the group consisting of lipoamide, dihydrolipoic acid, dihydrolipoamide, an ester derivative of α-lipoic acid, an ester derivative of dihydrolipoic acid, asparagusic acid, an ester derivative of asparagusic acid, 3,3′-dimercapto-isobutyric acid, an ester derivative of 3,3′-dimercapto-isobutyric acid, any salt or solvate thereof, or any combinations thereof, wherein the ester derivative is a methyl, ethyl, propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, benzyl, or stearyl ester, and at least one antimicrobial agent selected from the group consisting of doxycycline, levofloxacin, and gentamicin, wherein the α-lipoic acid or an analog thereof and the at least one antimicrobial agent have synergistic antimicrobial activity.
Dependencies are inferred from the claim text.