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US 9,956,316 B2Granted
Method for enzymatic treatment of tissue products
AssigneeLifeCell Corporation
InventorYi Chen
Life of this patent
Estimating the term…
Abstract
Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix.
Claims9
A method for treating a tissue matrix, comprising:
- selecting a dermal tissue matrix that does not contain epidermis;
- treating the dermal tissue matrix with a first solution to remove substantially all cells and cellular components from the dermal tissue matrix;
- and
- contacting the dermal tissue matrix with a second solution comprising a proteolytic enzyme under conditions sufficient to produce a desired level of pliability in the dermal tissue matrix and to increase the porosity of the dermal tissue matrix, wherein the enzyme is selected from bromelain, papain, ficin, actinidin, or combinations thereof.
1 more element
A method for treating a tissue matrix, comprising:
- selecting dermal acellular tissue matrix that does not contain epidermis;
- and
- contacting the dermal acellular tissue matrix with a proteolytic enzyme under conditions sufficient to produce a desired level of pliability in the dermal acellular tissue matrix and to increase the porosity of the dermal acellular tissue matrix, wherein the enzyme is selected from bromelain, papain, ficin, actinidin, or combinations thereof.
Dependencies are inferred from the claim text.