Compounds and compositions for the treatment of ocular disorders

A compound of Formula IV′:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R42 is selected from
• (i) —N═CH—C3-C30alkenylR5, —N═CH—C3-C30alkynylR5, —N═CH—C3-C30alkenylalkynylR5, —N═C1-C30alkylR5, —N═CH—C3-C30alkenyl, —N═CH—C3-C30alkynyl, —N═CH—C3-C30alkenylalkynyl, —N═C1-C30alkyl, —NHC3-C30alkenylR5, —NH—C3-C30alkynylR5, —NH—C5-C30alkenylalkynylR5, —NHC0-C30alkylR5, —NHC3-C30alkenylR16, —NH—C3-C30alkynylR16, —NH—C5-C30alkenylalkynylR16, and —NHC0-C30alkylR16;
• (ii) an imine, amine or amide linked unsaturated fatty acid residue selected from a derivative of linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, alpha-linolenic acid, stearidonic acid, y-linolenic acid, arachidonic acid, docosatetraenoic acid, palmitoleic acid, vaccenic acid, paullinic acid, oleic acid, elaidic acid, gondoic acid, euric acid, nervonic acid and mead acid;
• (iii) an amine or amide linked polypropylene glycol, an amine or amide linked polypropylene oxide, an amine or amide linked polylactic acid, an amine or amide linked polylactic-co-glycolic acid),
• an amine or amide linked polyglycolic acid, a polyester, and a polyamide;
• or
• (iv) —NHC(O)C1-20alkyl, —NHC(O)C1-20alkenyl, —NHC(O)C1-20alkynyl, —NHC(O)(C1-20alkyl with at least one R5 substituent on the alkyl chain), —NHC(O)(C1-20alkenyl with at least one R5 substituent on the alkenyl chain) —NHC(O)(C1-20alkynyl with at least one R5 substituent on the alkynyl chain), —NH(lactic acid)2-20C(O)C1-20alkyl, —NH(lactic acid)2-10C(O)C1-20alkyl, —NH(lactic acid)4-20C(O)C1-20alkyl, —NH(lactic acid)2-20C(O)C1-10alkyl, —NH(lactic acid)2-20C(O)C4-10alkyl, —NH(lactic acid)2-20C(O)OH, —NH(lactic acid)2-10C(O)OH, —NH(lactic acid)4-20C(O)OH, —NH(lactic acid)2-10C(O)OH, —NH(lactic acid)4-10C(O)OH, —NH(lactide-co-glycolide)2-10C(O)C1-20alkyl, —NH(lactide-co-glycolide)4-10C(O)C1-20alkyl, —NH(lactide-co-glycolide)2-10C(O)C1-10alkyl, —NH(lactide-co-glycolide)2-10C(O)C4-20alkyl, —NH(glycolic acid)2-10C(O)C1-10alkyl, —NH(glycolic acid)4-10C(O)C1-10alkyl, —NH(lactic acid)4-10C(O)C1-10alkyl, —NH(lactic acid)2-10C(O)C1-10alkyl, NH(lactic acid)2-10C(O)C4-10alkyl, —NH(lactic acid)2-10C(O)C4-10alkyl, and —NH(lactic acid)2-10C(O)C4-10alkyl;
• R15 is R17;
• R16 is selected from:
• (i) —C(O)C3-C30alkylR5, —C(O)C3-C30alkenylR5, —C(O)C3-C30alkynylR5, —C(O)C3-C30alkenylalkynylR5, —C(O)C3-C30alkyl, —C(O)C3-C30alkenyl, —C(O)C3-C30alkynyl, and —C(O)C3-C30alkenylalkynyl;
• (ii) an unsaturated fatty acid residue selected from linoleic acid, docosahexaenoic acid, eicosapentaenoic acid, alpha-linolenic acid, stearidonic acid, y-linolenic acid, arachidonic acid, docosatetraenoic acid, palmitoleic acid, vaccenic acid, paullinic acid, oleic acid, elaidic acid, gondoic acid, euric acid, nervonic acid, and mead acid;
• or
• (iii) polyethylene glycol, polypropylene glycol, polypropylene oxide, polylactic acid, poly(lactic-co-glycolic acid)
• polyglycolic acid, or a polyester, poly amide, or other biodegradable polymer;
• R17 is H or —C(O)A;
• A is selected from H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, and alkyloxy;
• R5 is selected from halogen, hydroxyl, cyano, mercapto, amino, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, aryloxy, —S(O)2alkyl, —S(O)alkyl, —P(O)(Oalkyl)2, B(OH)2, —Si(CH3)3, —COOH, —COOalkyl, and —CONH2;
• and
• x and y are selected from an integer between 1 and 30.