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US 9,956,299 B2Granted
Pyrrolobenzodiazepine—antibody conjugates
AssigneeMedImmune, LLC
InventorsPhilip Wilson Howard, Patricius Hendrikus Cornelis Van Berkel
Life of this patent
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Abstract
Conjugates of specific PBD dimers with an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
Claims12
A conjugate of formula
- wherein:
- the drug loading is an integer from 1 to about 8;
- Ab is an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
Dependencies are inferred from the claim text.