Highly concentrated stable meloxicam solutions
AssigneeBoehringer Ingelheim Vetmedica GmbH
InventorsStefan Henke, Bernd Kruss, Bernhard Hassel, Hans-Juergen Kroff, Martin A. Folger, Klaus Daneck, Axel Prox
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Abstract
Aqueous cyclodextrin-free solution of meloxicam for administration by oral or parenteral route, containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipients, the content of dissolved meloxicam salt being more than 10 mg/mL. The solution is for treating a mammal suffering from one or more of pain, inflammation, fever, acute mastitis, diarrhea, lameness, locomotor deficiency, or respiratory illness.
Claims4
A treatment method for treating non-human a mammal suffering from one or more of pain, inflammation, fever, acute mastitis, diarrhea, lameness, locomotor deficiency, or respiratory illness, the method comprising administering to the mammal an aqueous, cyclodextrin-free solution, the solution comprising:
- meloxicam in an amount of 20 mg/ml;
- meglumine in an amount of 14 mg/ml;
- a polyethylene glycol in an amount of 150 mg/ml;
- a polyoxyethylene-polyoxypropylene copolymer in an amount of 50 mg/ml;
- ethanol in an amount of 150 mg/ml;
- glycine in an amount of 5 mg/ml;
- disodium EDTA in an amount of 1 mg/ml;
- hydrochloric acid and/or sodium hydroxide provided in an amount sufficient to yield a pH of 8.8 of the solution;
- and
- water.
A treatment method for treating a non-human animal suffering from one or more of pain, inflammation, fever, acute mastitis, diarrhea, lameness, locomotor deficiency, or respiratory illness, the method comprising administering to the animal an aqueous, cyclodextrin-free solution, the solution consisting of:
- meloxicam in an amount of 20 mg/ml;
- meglumine in an amount of 14 mg/ml;
- a polyethylene glycol in an amount of 150 mg/ml;
- a polyoxyethylene-polyoxypropylene copolymer in an amount of 50 mg/ml;
- ethanol in an amount of 150 mg/ml;
- glycine in an amount of 5 mg/ml;
- disodium EDTA in an amount of 1 mg/ml;
- hydrochloric acid and/or sodium hydroxide provided in an amount sufficient to yield a pH of 8.8 of the solution;
- and
- water.
Dependencies are inferred from the claim text.