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US 9,956,282 B2Granted
Bacterial compositions and methods of use thereof for treatment of immune system disorders
AssigneeSeres Therapeutics, Inc.
InventorsDavid N. Cook, David Arthur Berry, Geoffrey von Maltzahn, Matthew R. Henn, Han Zhang, Brian Goodman
Life of this patent
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Abstract
Provided are compositions containing combinations of bacteria useful for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract, or other niche of a mammalian subject, and methods for use thereof, in particular for the treatment, inhibition, or prevention of immune disorders such as allergies and asthma.
Claims11
A method of identifying a bacterial composition useful for treating, preventing, or reducing the severity of an allergic effect, the method comprising:
- a) subjecting a test subject or group of test subjects to an antibiotic treatment;
- b) administering a bacterial test composition to the test subject or group of test subjects;
- c) administering an allergen to the test subject or group of test subjects;
- d) measuring an allergic effect in the test subject or group of test subjects;
- e) comparing the allergic effect measured in the test subject or group of test subjects to an allergic effect measured in a corresponding control subject or group of control subjects;
- and
- f) identifying the bacterial test composition as useful for treating, preventing or reducing the severity of an allergic effect if the allergic effect measured in the test subject or group of test subjects is less than the allergic effect measured in the corresponding control subject or group of control subjects.
4 more elements
Dependencies are inferred from the claim text.