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US 9,956,279 B2Granted
Vaccine for PCV2 and mycoplasma
AssigneeProtaTek International, Inc.
InventorsShi Jun Ma, Jing Sui
Life of this patent
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Abstract
A premixed multivalent vaccine in ready-to-use form comprising PCV2 ORF2 capsid antigen and M. hyopneumoniae antigen that reduces or prevents PCV2 infection and/or M. hyopneumoniae infection in pigs after a single dose administration of the vaccine is disclosed.
Claims16
A method of reducing PCV2 infection in a pig, comprising administering to the pig a single dose of a multivalent vaccine comprising:
- at least 1 ELISA unit of recombinant PCV2 ORF2 capsid antigen, wherein the ELISA unit is determined by PCV2-Ag-51811 as the reference antigen;
- at least 60 micrograms of Mycoplasma hyopneumoniae antigen;
- a two component adjuvant system, the first component comprising a saponin adjuvant and the second component comprising an oil-in-water adjuvant or aluminum adjuvant;
- and
- a physiologically acceptable vehicle.
2 more elements
A method of eliciting an immune response to PCV2 and Mycoplasma hyopneumoniae in a pig the method comprising:
- administering a single dose of a multivalent vaccine within 1 to weeks of birth, the vaccine comprising:
- at least 1 ELISA unit of recombinant PCV2 ORF2 capsid antigen, wherein the ELISA unit is determined by PCV2-Ag-51811 as the reference antigen;
- 60-180 micrograms of Mycoplasma hyopneumoniae antigen;
- a two component adjuvant system, the first component comprising a saponin adjuvant and the second component comprising an oil-in-water adjuvant or aluminum adjuvant;
- and
- a physiologically acceptable vehicle.
3 more elements
Dependencies are inferred from the claim text.