Back to results
US 9,956,254 B2Granted
Extract of taiwanese propolis for treating ocular diseases
AssigneeNaturewise Biotech & Medicals Corporation
InventorChi Chou Liao
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for treating an ocular disease in a subject in need thereof, comprising administering an effective amount of an extract of Taiwanese propolis (TP) or an active component thereof to the subject. Also provided is a pharmaceutical composition for treating an ocular disease, which comprises an effective amount of an extract of TP or an active component thereof, and a pharmaceutically acceptable carrier.
Claims10
A method for treating an ocular disease in a subject in need thereof, comprising
- administering to the subject an extract of Taiwanese propolis (TPE) in an amount effective to enhance the viability of RPE cells suffering from oxidative stress and/or hypoxia-induced damages, and at the same time having little or no effect on the viability of human umbilical vein endothelial cells (HUVECs),
- wherein the TPE is prepared from Taiwanese propolis by a method comprising the following steps:
- (i) extracting Taiwanese propolis with 95% ethanol for about 48 hours at 45° C. to obtain a first extract;
- (ii) collecting a soluble fraction of the first extract containing propolins;
- and
- (iii) concentrating the soluble fraction by about 4 times to obtain the TPE,
- whereby each gram of TPE contains no less than 100 mg of propolin C, 80 mg of propolin D, 30 mg of propolin F and 50 mg of propolin G, and each gram of TPE contains no less than 350 mg of total propolins.
4 more elements
Dependencies are inferred from the claim text.