Therapeutic monosaccharide-based inhibitors of hexokinase and glucokinase for parasitic diseases, along with methods of their formation and use
AssigneeUniversity of South Carolina
InventorsEdward L. D'Antonio, Jennifer D'Antonio
Life of this patent
Estimating the term…
Abstract
Methods for treating a mammal that is infected by a parasitic organism are provided, along with pharmaceutical compositions and compounds. The method includes administering to the mammal the pharmaceutical composition of FIG. 1, where: R1, R2, R3, and R4 comprises, independently, H, OH, NH2, SH, a halogen, or an organic group or a derivative thereof; X1 is O, NH, CH2, or S; m is 0 or 1; X2 comprises an organic linkage, such as CH2; n is an integer from 0 to 10; and R5 comprises an aromatic organic group.
Claims15
A method of treating a mammal that is infected by a parasitic organism, the method comprising:
- administering to the mammal a pharmaceutical compound having the structure
- where:
- R1, R2, R3, and R4 comprises, independently, H, OH, NH2, SH, or an organic group;
- X1 is O, NH, CH2, or S;
- m is 1;
- X2 comprises an organic linkage;
- n is an integer from 0 to 10;
- and
- R5 comprises an aromatic organic group.
A method of treating a mammal that is infected by a parasitic organism, the method comprising administering to the mammal a pharmaceutical compound having the structure
A compound having the structure
A compound having the structure
Dependencies are inferred from the claim text.