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US 9,956,236 B2Granted
Methods for increasing immune responses using agents that directly bind to and activate IRE-1
AssigneeCornell University
InventorsLaurie H. Glimcher, Sarah Bettigole, Fabio Martinon
Life of this patent
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Abstract
The invention provides, e.g., compositions and methods for increasing activation of immune cells.
Claims10
A method for increasing activation of immune cells in a subject, comprising administering at least one toll-like receptor (TLR) agonist and a human immunodeficiency virus (HIV) protease inhibitor that activates IRE-1 in the subject thereby increasing activation of immune cells in the subject, wherein the toll-like receptor (TLR) agonist stimulates TLR4;
- and contacting the immune cells with an antigen to which an immune response is desired.
Dependencies are inferred from the claim text.