Acyclic cucurbit[n]uril type molecular containers to treat intoxication and decrease relapse rate in substance abuse disorders
AssigneesUniversity of Maryland, College Park, The General Hospital Corporation
InventorsLyle David Isaacs, Matthias Eikermann, Cristina Cusin, Joseph Cotten
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Abstract
Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.
Claims14
A method for treating an individual in need of treatment for intoxication from ingestion of a drug, wherein the drug is selected from the group consisting of cocaine, fentanyl, methamphetamine, and combinations thereof, comprising administering to the individual a composition comprising a compound having the following structure, or a salt thereof, a partial salt thereof, or a mixture thereof, a stereoisomer thereof, or combinations thereof:
- wherein each R is independently hydrogen, C1 to C20 alkyl group, C3 to C20 carbocyclic group, C1 to C20 heterocyclic group, carboxylic acid group, ester group, amide group, hydroxy group or ether group;
- wherein, optionally, adjacent R groups form a C3 to C20 carbocyclic ring or heterocyclic ring;
- wherein each
- is independently a C5 to C20 carbocyclic ring system or C2 to C20 heterocyclic ring system, wherein the ring system comprises one or more rings;
- wherein at least one ring system has at least one solubilizing group selected from sulfonic acid group, sulfonate salt group, phosphonic acid group, phosphonate salt group, and polyethylene glycol group;
- wherein, optionally, the ring system has a targeting group;
- and
- wherein n is 1 to 5.
Dependencies are inferred from the claim text.