Substituted naphthyridine and quinoline compounds as MAO inhibitors

A method of treating a subject in need of enhancement of memory or cognition, comprising administering to the subject in need of such treatment an effective amount of at least one chemical entity, wherein the chemical entity is selected from the group consisting of compounds of Formula (I) and pharmaceutically acceptable salts of compounds of Formula (I)

• wherein:
• n is 1 or 2;
• Y is CH;
• R1 is a pyridine substituted with -CF3, or phenyl substituted only in the meta and para positions with a total of one, two, or three Ra members;
• each Ra is independently selected from the group consisting of halo, -C1-4alkyl, CF3, -NO2, and -OCi-4alkyl;
• R2 is -C(Rb)2Rc or -CO-Rd;
• each Rb is independently selected from the group consisting of -H, -F, and -C1- 3alkyl, or optionally two Rb members are taken together with the carbon to which they are attached to form a C3-6cycloalkyl ring;
• Rc is selected from the group consisting of -F, -NH2, -OH, -OCi-3alkyl, -CH2OH, -CN, -0O2-C1-4alkyl, -CO-NHRe, and -C(CH3)20H;
• provided that when at least one Rb is -F then Rc is not -F;
• Rd is selected from the group consisting of -CH3, OCi-4alkyl, -NHRe, and -NHCH2CH2N(Re)2;
• each Re is independently -H or -CH3;
• and
• R3 is selected from the group consisting of -H, -CH3, -OH, and -CF3.