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US 9,956,207 B2Granted
Antifungal compounds
AssigneeAmplyx Pharmaceuticals, Inc.
InventorsJonathan A. Covel, Mitchell Mutz, Peter J. Webb, Robert Remme Webb, II
Life of this patent
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Abstract
The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods for their use and compositions containing the same.
Claims23
An antifungal composition formulated in effective unit dosage and comprising an antifungal compound of formula (I)
- wherein:
- “a” is a double bond that may be present provided that R5a is not present;
- R1 is selected from alkyl, alkenyl, or is taken together with R3 or R3a to form a cycle;
- R3 and R3a are independently selected from —H, and —OH, or R3 and R3a together form ═X, where X is selected from O, C, and N such that ═X and the carbon atom to which it is attached forms a carbonyl, oxime, substituted oxime, imine, substituted imine, hydrazone, substituted hydrazone, terminal olefin, or substituted olefin functional group, or wherein one of R3 and R3a is —H and the other is taken together with R1 or R5 or R5a to form a cycle;
- R5 and R5a are independently selected from —H, —OH, or —OTBS, or R5 and R5a together form ═O, or one of R5 and R5a is —H and the other is taken together with R3 or R3a to form a cycle;
- R7 is a substituted carboxyl selected from:
- and R7a is —H;
- and
- R9 is selected from —H and —OH,
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.