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US 9,956,202 B2Granted
Use of indolyl and indolinyl hydroxamates for treating neurodegenerative disorders or cognitive decicits
AssigneeTaipei Medical University
InventorKuo Sheng Hung
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Abstract
The present invention relates to novel use of indolyl and indolinyl hydroxamates. Particularly, the invention relates to use of indolyl and indolinyl hydroxamates in the manufacturing a medicament or a pharmaceutical composition for treating a ischemic and hemorrhagic stroke, spinal cord injury, cranial nerve injury, peripheral nerve injury and a neurodegenerative disorder or cognitive deficit.
Claims11
A method for reducing neuronal loss and increasing locomotor function after spinal cord injury in a subject, comprising administering to the subject a therapeutically effective amount of the compound having formula (I),
- wherein is a single or double bond;
- B is SO2R;
- C is H;
- Xa, Xc and Xd are H;
- Xb is CH═CHC(O)NHOH;
- and R is H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.