Compositions comprising bioreversible derivatives of hydroxy N-substituted-2-aminotetralins, and related dosage forms
AssigneeSpriaso LLC
InventorsWilliam I. Higuchi, Firoozeh Aminian Patel
Life of this patent
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Abstract
Described are compositions that may be orally administered that comprise a bioreversible derivative of hydroxy N-substituted-2-aminotetralin or an enantiomer or salt or prodrug thereof, and a pharmaceutically acceptable carrier suitable for oral administration in the amount present, wherein the composition is orally bioavailable when administered to a subject. The bioreversible derivative has an intrinsic lipophilicity C log P value of about 7 to about 11.5. A method comprises oral administering such composition to a human subject in need of hydroxy N-substituted-2-aminotetralin therapy.
Claims22
A composition comprising:
- a bioreversible derivative of Formula I:
- or an enantiomer or salt of said bioreversible derivative;
- and
- a pharmaceutically acceptable carrier,
- wherein R1 is selected from the group consisting of butyl enanthate, methyl isocaprate, methyl caprate, isoundecanoate, diethyl enanthate, methyl propyl enanthate, ethyl propyl caproate, R-methyl undecanoate, dipropyl caproate, ethyl propyl enanthate, diethyl caprylate, propyl methyl caprylate, methyl isoundecanoate, isolaurate, dimethyl caprate, methyl isolaurate, isotridecanoate, methyl ethyl caprate, butyl nanoate ester, diethyl nanoate, methyl propyl nanoate, methyl laurate, ethyl propyl caprylate, methyl butyl caprylate, dipropyl caprylate, heptyl caproate, butyl propyl enanthate, methyl isolaurate, isomyristate, methyl tridecanoate, dimethyl isolaurate, dimethyl laurate, ethyl laurate, propyl undecanoate, trimethyl undecanoate, methyl ethyl undecanoate, butyl caprate, diethyl caprate, methyl propyl caprate, tetramethyl caprate, ethyl propyl nanoate, methyl butyl nanoate, pentyl nanoate, dipropyl caprylate, dibutyl caproate, propyl butyl enanthate, methyl myristate, ethyl myristate, cyclohexanoate, cyclohexyl pentanoate, cyclohexyl heptanoate, 2,4,6-trimethyl cyclohexyl propionate, 2,4,6-triethyl cyclohexyl propionate, 2,4,6-trimethyl cyclohexanoate, 2,4,6-triethyl cyclohexanoate, 2,4,6-tripropyl cyclohexanoate, mono-unsaturated enanthate, mono-unsaturated decanoate, diunsaturated decanoate, myristoleate, palmitolinoleate, lauraoleate, carbamate, dipropyl carbamate, dibutyl carbamate, dihexyl carbamate, benzoate, 2-methyl benzoate, 2-dimethyl benzoate, 2,4,6-trimethyl benzoate, 2-amino benzoate, dipentyl carbamate, 2-methoxy benzoate, 2-butoxy benzoate, propyl carbamate, tridecanoate, cypionate, buciclate, propyl caprate, undecanoate, laurate, myristate, and palmitate.
Dependencies are inferred from the claim text.