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US 9,956,190 B2Granted
Topical compositions for pain relief, manufacture and use
AssigneeVizuri Health Sciences LLC
InventorsPhilip J. Birbara, Daniel Bucks
Life of this patent
Estimating the term…
Abstract
The present invention relates to TRPV1 selective agonist compositions including a capsaicinoid, a surfactant and an extended release agent, and to methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
Claims69
A composition comprising:
- i) 0.2-20% by weight of capsaicinoid,
- ii) 0.1-0.5% by weight of hyaluronic acid, wherein said hyaluronic acid is a mixture of both low molecular weight hyaluronic acid and high molecular weight hyaluronic acid,
- iii) 0.5-15% by weight nonionic surfactant,
- wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
1 more element
A composition comprising:
- i) 2-20% by weight of capsaicinoid,
- ii) 0.2-0.5% by weight of hyaluronic acid, and
- iii) 2-15% by weight nonionic surfactant,
- wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
1 more element
A composition comprising:
- i) 0.20-20% by weight of a capsaicinoid,
- ii) 0.1-0.5% by weight hyaluronic acid,
- iii) 2-15% by weight PS 80 or polyoxy 40 hydrogenated castor oil, and
- iv) 1-40% by weight penetration enhancer,
- wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
2 more elements
A composition comprising:
- i) 0.20-20% by weight of a capsaicinoid,
- ii) 0.1-1.5% by weight hyaluronic acid,
- iii) 2-15% by weight PS 80 or polyoxy 40 hydrogenated castor oil, and
- iv) 1-40% by weight of one or more penetration enhancers selected from the group consisting of DGME and propylene glycol,
- wherein said composition reduces or eliminates burning and stinging created by said capsaicinoid upon topical administration.
2 more elements
Dependencies are inferred from the claim text.