US 9,956,188 B2Granted

Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

AssigneeTonix Pharma Holdings Limited

InventorsMarino Nebuloni, Patrizia Colombo

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Abstract

The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.

Claims9

Dependent claims

A eutectic of mannitol and cyclobenzaprine HCl, comprising 75%±2% cyclobenzaprine HCl and 25%±2% mannitol by weight.

Dependencies are inferred from the claim text.

Facts

Application: 15/459,093Filed 15 Mar 2017 · continuation
Priority: 15 Mar 2013
Published: US 2017/0239195 A124 Aug 2017
Granted: 1 May 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification26 codes

A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 9/145
Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried,…: with…
A61K 9/1623
Organic compounds, e.g. phospholipids, fats: sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
A61K 9/1688
Processes: resulting in pure drug agglomerate optionally containing up to 5% of excipient

Family

Application61/792,757Us provisional application · filed 15 Mar 2013
Application14/214,433Parent of this continuation · filed 14 Mar 2014
US 2017/0239195 A1Pre-grant publication · published 24 Aug 2017
US 9,636,408 B2Parent of this continuation
US 2014/0336264 A1Published application
US 9,956,188 B2This patent

From the US filing history. Foreign family members aren’t listed.

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