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US 9,956,175 B2Granted
Nanoparticles delivery systems, preparation and uses thereof
AssigneeNanobiotix
InventorsAgnès Pottier, Laurent Levy, Marie-Edith Meyre, Matthieu Germain
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AssigneeNanobiotix
InventorsAgnès Pottier, Laurent Levy, Marie-Edith Meyre, Matthieu Germain
Estimating the term…
The invention pertains to thermosensitive liposomes encapsulating nanoparticles. In certain embodiments, the thermosensitive liposomes of the invention disrupt when heated at gel-to-liquid crystalline phase transition temperature (Tm) or above Tm, wherein the liposome comprises a thermosensitive lipidic membrane encapsulating nanoparticles. The nanoparticles used in the invention comprise an inorganic core the largest dimension of which is less than about 100 nm that is fully coated with an agent responsible for the presence of an electrostatic charge below −20 mV or above +20 mV at the surface of the nanoparticle, the electrostatic charge being determined by zeta potential measurements in an aqueous medium between pH 6 and 8, for a concentration of nanoparticles in suspension in the aqueous medium varying between 0.2 and 8 g/L. The invention also relates to pharmaceutical and diagnostic compositions comprising the thermosensitive liposomes as well as to their uses.
A thermosensitive liposome comprising a thermosensitive lipidic membrane encapsulating nanoparticles, said thermosensitive lipidic membrane having a main phase transition temperature (Tm) between 39° C. and 55° C. and releasing said nanoparticles when heated to gel-to-liquid crystalline phase transition temperature (Tm) of between 39° C. and 55° C., the nanoparticles i) comprising an inorganic core the largest dimension of which is less than about 100 nm, and ii) being fully coated with an agent responsible for the presence of an electrostatic charge below −20 mV or above +20 mV at the surface of the nanoparticle, the electrostatic charge being determined by zeta potential measurements in an aqueous medium between pH 6 and 8, for a concentration of nanoparticles in suspension in the aqueous medium varying between 0.2 and 8 g/L.
Dependencies are inferred from the claim text.