Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof

A method of making a dry powder pharmaceutical composition comprising:

• providing an inactive ingredient comprising particles;
• providing a micronized active ingredient;
• and
• mixing surface-modified nanoparticles with the inactive ingredient particles and, separately, mixing surface-modified nanoparticles with the micronized active ingredient;
• wherein mixing the surface-modified nanoparticles with the inactive ingredient particles provides an inactive ingredient comprising particles having surfaces with the surface-modified nanoparticles deposited on the surfaces, wherein mixing the inactive ingredient particles with the surface-modified nanoparticles is carried out in a liquid, and then the liquid is removed, and wherein the inactive ingredient particles are insoluble in the liquid, and the surface-modified nanoparticles are dispersible in the liquid;
• and
• wherein mixing the surface-modified nanoparticles with the micronized active ingredient provides a micronized active ingredient comprising particles having surfaces with the surface-modified nanoparticles deposited on the surfaces, wherein mixing the micronized active ingredient with the surface-modified nanoparticles is carried out in a liquid, and then the liquid is removed, and wherein the micronized active ingredient is insoluble in the liquid, and the surface-modified nanoparticles are dispersible in the liquid;
• and
• then mixing the micronized active ingredient comprising particles having surfaces with the surface-modified nanoparticles deposited on the surfaces with the inactive ingredient comprising particles having surfaces with the surface-modified nanoparticles deposited on the surfaces.