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US 9,956,168 B2Granted
Extended release drug-delivery contact lenses and methods of making
AssigneeMercy Medical Research Institute
InventorsKeela Davis, Martin Reuter, Anthony Kammerich, Andrew Tangonan, Kumar Vedantham, Anna Kelley
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Abstract
Contact lenses are described that include particles of polymer fiber mat incorporated into a polymer lens wherein the polymer fiber mat is formed by electrospinning a prepolymer solution. Methods for making the contact lenses with improved oxygen permeability are also described. Methods for making the contact lens with optional therapeutic drug delivery and refractive correction are also described.
Claims40
A process for forming a contact lens comprising the steps of electrospinning a mat of polymer fibers;
- applying a cross-linking treatment to the mat of polymer fibers;
- cooling the mat of polymer fibers;
- freezing the polymer fibers;
- processing the mat of frozen polymer fibers into particles, wherein the polymer fibers are kept frozen during processing into particles;
- isolating the particles having dimensions less than or equal to 500 micrometers, wherein isolating the particles includes sieving, gravity separation, electrostatic separation or combinations thereof;
- and incorporating the particles into a contact lens.
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Dependencies are inferred from the claim text.