Systems, methods, and devices for monitoring and treatment of tissues within and/or through a lumen well

A system, comprising:

• a tool configured to monitor an electrophysiological activity in a vicinity of an anatomical site in a vicinity of an organ or vessel in a body, and to perform a surgical procedure on the anatomical site;
• and
• a control unit configured to accept signals from the tool, and to at least one of:
• adjust the surgical procedure dependent upon the signals, display the signals, evaluate the surgical procedure dependent upon the signals, plan a surgical path for the surgical procedure dependent upon the signals, and determine the extent of the procedure dependent upon the signals;
• wherein the tool comprises:
• an elongate member with a distal tip and a control end, the distal tip thereof shaped and dimensioned so as to fit within a lumen, the elongate member shaped and dimensioned so as to extend from an entry site on the body into the lumen;
• and
• one or more probes each configured with a probe tip, the probes deploy-ably coupled with the distal tip of the elongate member and at least one of electrically, mechanically, and fluidly coupled to the control end of the elongate member, the probe tips shaped so as to at least one of penetrate into and penetrate through a wall of the lumen upon deployment from the elongate member, one or more of the probes comprising one or more electrodes electrically coupled to the probes, one or more of the electrodes configured to at least one of convey a signal associated with an electrophysiological activity and to alter the electrophysiological activity upon deployment;
• and
• a controller configured:
• to record one or more electrophysiological signals from monitored electrophysiological activity within the vicinity of one or more of the electrodes coupled to the probes;
• to cancel one or more movement artifacts from the recorded electrophysiological signals utilizing a corrective signal, the corrective signal being generated from monitoring one or more physiological parameters of the subject at a location remote from the vicinity of the one or more electrodes coupled to the probes;
• and
• wherein the system is configured to alter electrophysiological activity in the vicinity of the anatomical site in the vicinity of the organ or vessel in the body accessible via the lumen.

A method, comprising:

• penetrating one or more probe tips of one or more probes at least one of into and through a wall of a vessel from within the vessel, the one or more probes being deploy-ably coupled with a distal tip of an elongate member of a tool, wherein one or more electrodes are coupled to one or more of the probes;
• and
• recording one or more electrophysiological signals from electrophysiological activity monitored within the vicinity of one or more of the electrodes coupled to the probes;
• generating a corrective signal from monitoring one or more physiological parameters at a location remote from the vicinity of the one or more electrodes coupled to the probes;
• and
• canceling one or more movement artifacts from the recorded electrophysiological signals utilizing the corrective signal to enable at least one of monitoring and altering electrophysiological activity in the vicinity of the vessel.