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US 9,955,886 B2Granted
Focused recording and stimulation electrode array
AssigneeThe Regents of the University of California
InventorsWentai Liu, Chih-Wei Chang
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Abstract
Neural signal recording apparatus and method is described, in which a micro electrode array is utilized for performing a weighted matrix as a moving window providing superpositioning of electrode signals. A voltage distribution across the electrode array is determined as a Laplacian. The apparatus and method can be utilized in a variety of electrode sensing applications involving registering neural activity, and for electrode stimulation applications, or combinations thereof.
Claims25
An apparatus for recording neural activity, comprising:
- (a) a micro electrode array configured for application to a target tissue area of the brain for which neural activity is to be recorded, with said micro electrode array comprising a plurality of electrodes, arranged in at least a two dimensional array, with the electrodes positioned so that recorded signal information from adjacent electrodes overlap one another;
- (b) multiple sub-array active circuits, each sub-array active circuit electrically coupled to a plurality of the electrodes of the micro electrode array and which receives data and control signals for performing recording and stimulation;
- (c) a computer processor having data and control signal lines connected to said multiple sub-array active circuits for controlling stimulation of said micro electrode array and processing signals from said micro electrode array;
- and
- (d) a non-transitory memory storing instructions executable by the processor;
- (e) wherein said instructions, when executed by the computer processor, perform steps comprising:
- (i) determining a weighting matrix, which spans an area of multiple electrode positions surrounding a center electrode position, for the micro electrode array based on a given electrode configuration;
- (ii) collecting neural signals from the micro electrode array;
- (iii) applying the weighting matrix to a window of collected neural signals to generate a superposition signal for the center electrode and its boundary area of recording power density;
- (iv) moving the window of the weighting matrix for different center electrode positions within the micro electrode array;
- and
- (v) recording neural activity for multiple electrodes in the micro electrode array to which said weighting matrix is applied in the moving window.
9 more elements
An apparatus for recording neural activity and performing neural stimulation, comprising:
- (a) a micro electrode array configured for application to a target tissue area of the brain for which neural activity is to be recorded, with said micro electrode array comprising a plurality of electrodes, arranged in at least a two dimensional array, with electrodes positioned so that recorded signal information from adjacent electrodes overlap one another;
- (b) multiple sub-array active circuits, each sub-array active circuit electrically coupled to a plurality of the electrodes of the micro electrode array and which receives data and control signals for performing recording and stimulation;
- (c) a computer processor having data and control signal lines connected to multiple sub-array active circuits for controlling stimulation of said micro electrode array and processing signals from said micro electrode array;
- and
- (d) a non-transitory memory storing instructions executable by the processor;
- (e) wherein said instructions, when executed by the computer processor, perform steps comprising:
- (i) determining a weighting matrix, which spans an area of multiple electrode positions in a window surrounding a center electrode position, for the micro electrode array based on electrode configuration;
- (ii) collecting neural signals from the micro electrode array;
- (iii) applying the weighting matrix to collected neural signals to generate a superposition signal for the center electrode and its boundary area of recording power density;
- (iv) moving the window of the weighting matrix for different center electrode positions within the micro electrode array;
- (v) recording neural activity for multiple electrodes in the micro electrode array to which said weighting matrix is applied in the moving window;
- and
- (vi) performing neural stimulation with a selectable current density distribution controlled by stimulation weighting of the weighting matrix.
10 more elements
An apparatus for generating neural stimulation, comprising:
- (a) a micro electrode array configured for application to a target tissue area of the brain for which neural stimulation is to be provided, with said micro electrode array comprising a plurality of electrodes, arranged in at least a two dimensional array, with the electrodes positioned so that stimulations generated from adjacent electrodes overlap one another;
- (b) multiple sub-array active circuits, each sub-array active circuit electrically coupled to a plurality of the electrodes of the micro electrode array and which receives data and control signals for performing recording and stimulation;
- (c) a computer processor having data and control signal lines connected to said multiple sub-array active circuits for controlling stimulation from said micro electrode array and processing signals from said micro electrode array;
- (d) a non-transitory memory storing instructions executable by the processor;
- and
- (e) wherein said instructions, when executed by the computer processor, perform steps comprising:
- (i) determining a weighting matrix, which spans an area of multiple electrode positions in a window surrounding a center electrode position, for the micro electrode array based on electrode configuration;
- (ii) performing neural stimulation with a selectable current density distribution controlled by stimulation weighting of the weighting matrix;
- and
- (iii) moving the window of the weighting matrix for different center electrode positions within the micro electrode array;
- (iv) whereby in response to neural stimulation at different moving window positions stimulation is provided to multiple electrodes in the micro electrode array.
8 more elements
Dependencies are inferred from the claim text.