US 9,952,217 B2 · Anti-HBc quantitative detection method and uses thereof in monitoring and controlling disease progression of chronic hepatitis B patient and in predicting therapeutic effect

Abstract

The present invention relates to a method for quantitative detection of anti-HBc and its use in monitoring disease progression of chronic hepatitis B patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis B core protein (Anti-HBc), it is able to monitor disease progression of chronic hepatitis B patients, effectively predict therapeutic effects in chronic hepatitis B patients who accept a therapy against hepatitis B virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analog anti-HBV drug), and thus guide the patients to reasonably choose drugs.

Claims12

Dependent claims

A method for treatment of a chronic hepatitis B patient, comprising:

(a) quantitative detection of the level of total antibodies against hepatitis B virus core protein (HBc) in a serum sample of the chronic hepatitis B patient before the chronic hepatitis B patient accepts a drug against hepatitis B virus;
and
(b1) administering a nucleoside or nucleotide analog to the chronic hepatitis B patient if the level of total antibodies against HBc is higher than 29000 IU/mL;
or
(b2) administering an interferon to the chronic hepatitis B patient if the level of total antibodies against HBc is lower than 29000 IU/mL.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/373,611Filed 17 Jan 2013

Priority

CN 2012 1 001938921 Jan 2012

Published

US 2015/0118674 A130 Apr 2015

Granted

24 Apr 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

G01N 33/56983
For microorganisms, e.g. protozoa, bacteria, viruses: viruses
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00

Anti-HBc quantitative detection method and uses thereof in monitoring and controlling disease progression of chronic hepatitis B patient and in predicting therapeutic effect

Life of this patent

Anti-HBc quantitative detection method and uses thereof in monitoring and controlling disease progression of chronic hepatitis B patient and in predicting therapeutic effect

Life of this patent

Abstract

Claims12