PSMA binding ligand-linker conjugates and methods for using
AssigneePurdue Research Foundation
InventorsPhilip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
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Abstract
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Claims25
A conjugate or a pharmaceutically acceptable salt thereof, the conjugate or the pharmaceutically acceptable salt thereof comprising a ligand of PSMA (B), a linker (L), and a drug (D), wherein the ligand comprises a carbon-sulfur double bond, a phosphorus-sulfur double bond, a phosphorus-sulfur single bond, a thioester, or a combination thereof wherein the linker is covalently bound to the drug via a hydrazide linkage, wherein the linker is covalently bound to the ligand wherein the linker comprises a chain of at least seven atoms, and wherein the linker comprises a disulfide linkage.
Dependencies are inferred from the claim text.