Loading patent…
AssigneeUniversidad Nacional Autonoma De Mexico
InventorsLourival Domingos Possani Postay, María Martha Pedraza Escalona, Gerardo Pavel Espino Solis, Alejandro Olvera Rodríguez, Héctor Miguel Cardoso Torres
Estimating the term…
The invention relates to the production and the characterization of new murine monoclonal antibodies that recognize the domain CTDL-2 (SEQ ID NO: 1) of the cell receptor DEC-205 of dendritic cells in chickens (Gallus gallus), pigs, (Sus scrofa) and humans (Homo sapiens). The invention also relates to the capacity of the new antibodies to direct and modulate the immune response at different levels in chickens (Gallus gallus) and pigs (Sus scrofa), as well as recognizing the receptor DEC-205 in dentritic cells and cell lines in humans. In addition, the invention is used to quickly produce a specific humoral immune response against Hemaglutinina H5 of the H5N2-type avian flu virus.
An isolated antibody that recognizes the CTLD-2 domain of the DEC-205 receptor of Gallus gallus (SEQ ID NO. 1), comprising a fragment VH with an amino acid sequence SEQ ID NO. 15, and a fragment VL with a sequence SEQ ID NO. 13.
Dependencies are inferred from the claim text.