Loading patent…
AssigneeThe Governors of the University of Alberta
InventorsMichael Doschak, Arash Panahifar, Morteza Mahmoudi
Estimating the term…
Described herein are compositions having a nanoparticle that is conjugated to at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the nanoparticle by a linker, wherein the nanoparticle contains iron, and wherein the compositions are neutral or pharmaceutically acceptable salts or esters. Also described herein are methods of making these compositions. In one aspect, the nanoparticles serve as contrast agents for magnetic resonance imaging of bone metabolism. The compounds, compositions, and methods described herein can be used in a number of therapeutic applications including diagnosing or monitoring fracture and/or the progress of conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteopenia, and hypercalcemia.
An iron nanoparticle comprising a superparamagnetic iron oxide nanoparticle with a linker comprising two or more carboxylate groups coated on the surface of the nanoparticle and a bone targeting moiety covalently bonded to the linker via a carboxylate group on the linker, wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof.
A method of making an iron nanoparticle comprising:
Dependencies are inferred from the claim text.