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US 9,950,044 B2Granted
Treatment of pulmonary vascular remodeling with neprilysin
AssigneeThe Regents of the University of Colorado, a body corporate
InventorEdward C. Dempsey
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Abstract
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming from the inventor's discovery that Neprilysin is expressed at reduced levels in disease tissues.
Claims20
A method of treating pulmonary vascular remodeling in a subject comprising the steps of:
- (i) obtaining a tissue sample comprising lung tissue, pulmonary vascular muscle, endothelial cell tissue or fibroblast tissue from a subject;
- (ii) assessing the expression of neprilysin in cells of said sample;
- and
- (iii) providing to said subject neprilysin or a peptidase active fragment thereof when expression of neprilysin cells of said tissue sample is reduced as compared to a healthy cells.
1 more element
Dependencies are inferred from the claim text.