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US 9,950,043 B2Granted
Modulation of muscle and adipocyte distribution and fate
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorBrian Jay Feldman
Life of this patent
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Abstract
Modulation of the ADAMTS1 signaling pathway alters the commitment of progenitor cells to a muscle fate; and increases muscle mass.
Claims7
A method of enhancing myogenesis, the method comprising:
- contacting a population of human muscle satellite cells in vivo in an individual suffering from a myopathy with an effective dose of a polypeptide consisting of SEQ ID NO:4, wherein the dose is effective to increase muscle mass or to reduce loss of muscle mass in the individual.
A method of enhancing myogenesis, the method comprising:
- administering to an individual suffering from a myopathy an effective dose of a purified active fragment of human ADAMTS1 protein comprising SEQ ID NO:1, residues 258-463;
- thereby contacting a population of human muscle satellite cells, wherein the dose is effective to increase muscle mass or to reduce loss of muscle mass in the individual.
Dependencies are inferred from the claim text.