Hatching fluid enzymes and uses thereof
AssigneeAqua Bio Technology Asa
InventorsHans Kristian Leren, Bernt Th. Walther
Life of this patent
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Abstract
The present invention relates to various polypeptides from fish hatching fluid, their encoding nucleic acid sequences, pharmaceutical compositions comprising said polypeptides and nucleic acid molecules and their use in various medical and cosmetic applications to the skin, particularly for moisturizing skin and/or for exfoliation of the horny layer of the skin for treating or preventing skin disorders or conditions in an animal.
Claims8
A pharmaceutical or cosmetic composition comprising:
- (i) an isolated acidic polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2 or a sequence which is at least 90% identical to said sequence;
- (ii) an isolated acidic polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 3 or a sequence which is at least 90% identical to said sequence;
- or
- (iii) an isolated acidic polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 4 or a sequence which is at least 90% identical to said sequence;
- an effective amount of an added stabilizing agent wherein the stabilizing agent stabilizes the isolated acidic polypeptide from degradation,
- and one or more pharmaceutically or cosmetically acceptable excipients or diluents, wherein the composition is a gel, cream, ointment, lotion, foam, non-aqueous solution, spray, salve, stick, soap, powder, film, emulsion, suspension or dispersion.
A cosmetic or non-cosmetic method of moisturizing skin of an animal, said method comprising administering topically a polypeptide or pharmaceutical or cosmetic composition to said animal, wherein:
- (a) said polypeptide comprises:
- (i) an isolated acidic polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2 or a sequence which is at least 90% identical to said sequence;
- (ii) an isolated acidic polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 3 or a sequence which is at least 90% identical to said sequence;
- or
- (iii) an isolated acidic polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 4 or a sequence which is at least 90% identical to said sequence;
- and
- (b) said pharmaceutical or cosmetic composition comprises one or more polypeptides as set forth in (a) and one or more pharmaceutically or cosmetically acceptable excipients or diluents, wherein the composition is a gel, cream, ointment, lotion, foam, non-aqueous solution, spray, salve, stick, soap, powder, film, emulsion, suspension or dispersion.
Dependencies are inferred from the claim text.