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US 9,945,845 B2Granted
Methods of screening using amphibians
OwnerAndré W. Brändli, Roland E. Kälininventors
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Abstract
High-throughput methods of screening agents for activities affecting renal, cardiac, blood or lymphatic vascular development and functions in amphibians in multiwell plates are provided. Also provided are novel compounds that modulate blood and lymphatic vascular development.
Claims23
A method for in vivo screening to identify compounds that modulate fluid homeostasis having an underlying pathophysiological function in the cardiovascular, lymphatic, and excretory systems comprising:
- a) treating a plurality of amphibians with a plurality of agents;
- b) identifying an amphibian from the plurality of amphibians wherein the treatment causes edema in the amphibian;
- and c) determining the anatomical pattern of edema formation in the identified amphibian.
Dependencies are inferred from the claim text.