Chromosome 3p21.3 genes are tumor suppressors
AssigneesBoard of Regents, The University of Texas System, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsLin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
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Abstract
Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
Claims4
A method of altering the phenotype of a lung tumor cell comprising contacting said cell with an expression cassette comprising:
- (a) an isolated polynucleotide encoding a human FUS1 polypeptide;
- and
- (b) a heterologous promoter active in said tumor cell, under conditions permitting the uptake of said polynucleotide by said tumor cell.
Dependencies are inferred from the claim text.