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US 9,943,570 B2Granted
Manipulation of hairy and enhancer of split 3 (Hes3) and its regulators/mediators as an anti-cancer strategy
AssigneeTechnische UniversitäT Dresden
InventorAndreas Androutsellis-Theotokis
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Abstract
The present invention relates to an inhibitor of Hairy and Enhancer of Split 3 (Hes3) or for use in treating a tumor. The invention further relates to an in-vitro method for diagnosing a tumor, comprising determining the amount of Hes3 protein in a cerebrospinal fluid (CSF)-derived sample obtained from a subject, wherein an increased amount of Hes3 protein is indicative of the presence of a tumor.
Claims13
A method for treating a subject having a brain tumour, the method comprising:
- determining the amount of Hes3 protein in a cerebrospinal fluid (CSF) sample obtained from the subject;
- and
- administering to the subject an inhibitor of Hairy and Enhancer of Split 3 (Hes3) in a therapeutically effective amount to reduce the tumour burden or eradicate the tumour in the subject;
- wherein the inhibitor comprises an anti-Hes3 siRNA.
1 more element
Dependencies are inferred from the claim text.