Preeclamptic placental mesenchymal stem cell conditioned medium for use in the treatment of a tumour
AssigneeCorion Biotech S.R.L.
InventorsAlessandro Rolfo, Tullia Todros
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Abstract
It is described a conditioned medium (CM) obtainable by culturing, in a liquid culture medium, placental mesenchymal stem cells from a preeclamptic placenta. The conditioned medium object of the invention includes at least IP-10 and TARC proteins and it is used for the therapeutic treatment of a tumor, preferably an epithelial tumor.
Claims8
A method of altering the expression of genes associated with cancer in a patient affected by cancer, comprising administering a conditioned medium to the patient, wherein the conditioned medium is obtainable by culturing placental mesenchymal stem cells from a preeclamptic placenta in a serum-free basal liquid culture medium, the conditioned medium comprising at least interferon gamma-induced protein 10 (IP-10) and thymus activation-regulated chemokine (TARC), and wherein the genes associated with cancer comprise VEGF, JunB, PARP, CASP3, p16nk4A, or any combination thereof.
Dependencies are inferred from the claim text.