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US 9,943,526 B2Granted
Optimizing mifepristone levels for cushing's patients
AssigneeCorcept Therapeutics, Inc.
InventorsJoseph Belanoff, Coleman Gross
Life of this patent
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Abstract
The present invention provides a method for optimizing levels of mifepristone in a patient suffering from Cushing's syndrome. The method comprises the steps of treating the patient with seven or more daily doses of mifepristone over a period of seven or more days; testing the serum levels of the patient to determine whether the blood levels of mifepristone are greater than 1631 ng/mL; and adjusting the daily dose of the patient to achieve mifepristone blood levels greater than 1631 ng/mL.
Claims9
A method for treating a patient suffering from Cushing's syndrome, the method comprising:
- A) treating said patient with seven or more daily doses of mifepristone over a period of seven or more days, wherein each of said daily doses contains an initial amount of mifepristone;
- B) testing the plasma mifepristone levels of the patient;
- then
- C) if the plasma mifepristone levels of the patient are greater than 1631 ng/mL, continuing to treat the patient with said daily doses of mifepristone;
- or
- D) if the plasma mifepristone levels of the patient are less than or equal to 1631 ng/mL, continuing to treat the patient with daily doses of mifepristone, wherein each daily dose contains an amount of mifepristone that is greater than said initial amount of mifepristone;
- and
- E) repeating step B) and then step C) or step D);
- thereby
- adjusting the daily dose of the patient to achieve mifepristone plasma levels greater than 1631 ng/mL, with the proviso that the patient is not already suffering from a condition indicated for treatment with mifepristone,
- whereby mifepristone treatment optimized to achieve mifepristone plasma levels greater than 1631 ng/mL is provided to the patient suffering from Cushing's syndrome.
8 more elements
Dependencies are inferred from the claim text.