Inhibition of diacylglycerol kinase to augment adoptive T cell transfer
AssigneeThe Trustees of the University of Pennsylvania
InventorsSteven M. Albelda, Liang-Chuan Wang, Gary Koretzky, Matthew Riese
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Abstract
The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
Claims14
A composition with enhanced cytolytic activity, said composition comprising an inhibitor of diacylglycerol kinase (DGK) or a downstream effector protein thereof and a T cell modified with a chimeric antigen receptor (CAR).
An isolated T cell with enhanced cytolytic activity, wherein the T cell comprises an inhibitor of DGK or a downstream effector protein thereof and a chimeric antigen receptor (CAR).
Dependencies are inferred from the claim text.