Control of Varroa mite infestation
AssigneesThe University Court of the University of Aberdeen, The Secretary of State for Enviroment Food and Rural Affairs
InventorsAlan Stuart Bowman, Ewan McInnes Campbell, Giles Elliott Budge
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Abstract
Nucleic acid agents for reducing or removing infestations of the Varroa destructor mite are described. Compositions comprising the nucleic acid agents and methods for controlling mite infestations using the nucleic acid agents and compositions are also disclosed.
Claims24
An isolated nucleic acid agent comprising a nucleic acid sequence that is capable of downregulating the expression of a gene of the Varroa destructor mite, wherein the gene encodes Monoamine Oxidase (MOA;
- GenBank accession number ADDG01053234.1) (SEQ ID NO:
- 15), Acetylcholinesterase (AChE;
- GenBank accession number ADDG01069748.1) (SEQ ID NO:
- 16), vATPase subunit C (vATPc;
- GenBank accession number ADDG01035752.1) SEQ ID NO:
- 17), GABA-receptor alpha subunit (GABA-Rα;
- GenBank accession number ADDG01060981.1) (SEQ ID NO:
- 18), Chitin Synthase 1 (CHS-1;
- GenBank accession number ADDG01037469.1) (SEQ ID NO:
- 19), Pyruvate Kinase (PyK;
- GenBank accession number ADDG01095321.1) (SEQ ID NO:
- 20), Prothoracicostatic peptide precursor (PTTH;
- GenBank accession number ADDG01000788.1) (SEQ ID NO:
- 22), or Crustacean hyperglycaemic hormone (CHH;
- GenBank accession number ADDG01078386.1) (SEQ ID NO:
- 23), wherein the nucleic acid agent is selected from the group consisting of a double-stranded RNA (dsRNA), an antisense RNA, a ribozyme, and an isolated nucleic acid concatemer.
An isolated nucleic acid concatemer comprising at least a first nucleic acid sequence and a second nucleic acid sequence;
- wherein the first nucleic acid sequence is capable of down-regulating the expression of a first gene of the Varroa destructor mite, and the second nucleic acid sequence is capable of down-regulating the expression of a second gene of the Varroa destructor mite;
- wherein the concatemer optionally further comprises a third nucleic acid sequence, wherein the third nucleic acid sequence is capable of down-regulating the expression of a third gene of the Varroa destructor mite.
Dependencies are inferred from the claim text.