Stabilized mosaic human immunodeficiency virus type 1 (HIV-1) GP140 envelope (ENV) trimers
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsDan H. Barouch, Joseph Patrick Nkolola
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Abstract
The invention features isolated human immunodeficiency virus (HIV) envelope (Env) trimers, in which the amino acid sequence of the Env polypeptides is optimized to stabilize formation of the trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
Claims28
An isolated stabilized homotrimer comprising three gp140 polypeptides, wherein each of said gp140 polypeptides comprises the sequence of amino acids 30-724 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.