Substituted indoles

A compound having formula (I) or a pharmaceutically acceptable salt thereof

• wherein
• R1 is hydrogen, —C(O)(C1-C6 alkyl), —(C1-C6 alkylenyl)-OH, —C(H)(benzyl)-NH2, —C(H)(phenyl)-NH2, —(C1-C6 alkylenyl)-NR1AR1B, or —(C1-C6 alkylenyl)-N(Rj)C(O)R1C;
• R1A and R1B are each independently hydrogen, C1-C6 haloalkyl, C1-C6 alkyl, C2-C4 alkenyl, —(CH2)m-G1A, —(C1-C6 alkylenyl)-L1A-X, or —(CH2)n-G1A-L1B-G;
• or
• R1A and R1B together with the nitrogen atom to which they are attached, form a C5-C6 heterocycloalkyl which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C1-C6 haloalkyl, C1-C6 alkyl, and oxo;
• R1C is C1-C6 haloalkyl, C1-C6 alkyl, C2-C4 alkenyl, —(CH2)m-G1A, —(C1-C6 alkylenyl)-L1A-X, or —(CH2)n-G1A-L1B-G;
• G1A and G, at each occurrence, are each independently phenyl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle;
• wherein each G1A and G are optionally substituted with 1, 2, or 3 independently selected Ru;
• L1A, at each occurrence, is independently O, N(H), or C(O)O;
• X, at each occurrence, is independently H, C1-C6 alkyl, or C1-C6 haloalkyl;
• L1B, at each occurrence, is independently a bond, —C1-C3 alkylenyl, O, —O—C1-C3 alkylenyl-, C(O), or —N(H)C(O)—;
• m is 0, 1, or 2;
• n is 0, 1, or 2;
• R2 is hydrogen, halogen, C1-C6 alkyl, C2-C4 alkenyl, or G2A;
• wherein G2A is C3-C6 cycloalkyl, C5-C6 cycloalkenyl, phenyl, or C5-C6 heteroaryl;
• and each G2A is optionally substituted with 1, 2, or 3 independently selected Ru groups;
• R3 is hydrogen, halogen, C1-C6 alkyl, C2-C4 alkenyl, G3A, -G3A-GA, or -G3A-L3-Y;
• G3A, at each occurrence, is independently C5-C6 cycloalkenyl, C3-C6 cycloalkyl, phenyl, C5-C6 heteroaryl, heterocycle;
• wherein each G3A is optionally substituted with 1, 2, or 3 independently selected Ru groups;
• GA is C3-C6 cycloalkyl or C5-C6 heterocycloalkyl;
• each of which is optionally substituted with 1, 2, or 3 independently selected Ru groups;
• L3 is C1-C3 alkylenyl, C(O), or —C(O)N(H)—;
• Y is —(C1-C6 alkylenyl)-N(Rj)2, C3-C6 cycloalkyl, or C5-C6 heterocycloalkyl, wherein the C3-C6 cycloalkyl and the C5-C6 heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of C1-C3 alkyl, halogen, and C1-C3 haloalkyl;
• R4 is hydrogen, halogen, or —(C1-C6 alkylenyl)-C(O)NR4AR4B;
• wherein R4A and R4B are each independently hydrogen or C1-C6 alkyl;
• R5 is hydrogen, halogen, C2-C4 alkenyl, C1-C6 alkyl, or phenyl wherein the phenyl is optionally substituted with 1, 2, or 3 independently selected Ru groups;
• R6 is hydrogen, halogen, C1-C3 alkyl, or cyclopropyl;
• wherein the cyclopropyl is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C3 alkyl, and C1-C3 haloalkyl;
• Ru, at each occurrence, is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, C1-C6 haloalkyl, —CN, oxo, NO2, —ORj, —OC(O)Rk, —OC(O)N(Rj)2, —SRj, —S(O)2Rj, —S(O)2N(Rj)2, —C(O)Rj, —C(O)ORj, —C(O)N(Rj)2, —N(Rj)2, —N(Rj)C(O)Rk, —N(Rj)S(O)2Rk, —N(Rj)C(O)O(Rk), —N(Rj)C(O)N(Rj)2, —(C1-C6 alkylenyl)-ORj, —(C1-C6 alkylenyl)-OC(O)Rk, —(C1-C6 alkylenyl)-OC(O)N(W)2, —(C1-C6 alkylenyl)-SRj, —(C1-C6 alkylenyl)-S(O)2Rj, —(C1-C6 alkylenyl)-S(O)2N(Rj)2, —(C1-C6 alkylenyl)-C(O)Rj, —(C1-C6 alkylenyl)-C(O)ORj, —(C1-C6 alkylenyl)-C(O)N(Rj)2, —(C1-C6 alkylenyl)-N(Rj)2, —(C1-C6 alkylenyl)-N(Rj)C(O)Rk, —(C1-C6 alkylenyl)-N(Rj)S(O)2Rk, —(C1-C6 alkylenyl)-N(Rj)C(O)O(Rk), —(C1-C6 alkylenyl)-N(Rj)C(O)N(Rj)2, or —(C1-C6 alkylenyl)-CN;
• Rj, at each occurrence, is independently hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;
• and
• Rk, at each occurrence, is independently C1-C6 alkyl or C1-C6 haloalkyl.