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US 9,925,258 B2Granted
Replication-competent VSV-HIV Env vaccines
AssigneeInternational AIDS Vaccine Initiative
InventorsChristopher L. Parks, Wayne C. Koff
Life of this patent
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Abstract
The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
Claims10
A VeroCD4/CCR5 cell line infected with a recombinant vesicular stomatitis virus (VSV) vector wherein the gene encoding the VSV surface glycoprotein G (VSV G) is functionally replaced by functional clade A HIV Env BG505.
Dependencies are inferred from the claim text.